Reseasrch Projects
I. DYNAMICAL MODEL OF A TYPE II DNA TOPOISOMERASE BIOLOGICAL NANOMACHINE AND DESIGN OF CATALYTIC INHIBITORS
ARRS basic reserach project: J1-4402
Principal Investigator: dr. Andrej Perdih
II. DESIGN OF NOVEL Mur LIGASE INHIBITORS AND DYNAMICAL MODEL OF THE E. coli MurD ENZYME
ARRS basic postdoctoral reserach project: Z1-4111
Principal Investigator: dr. Andrej Perdih
III. DYNAMICS OF PROTON TRANSFER IN BIOLOGICAL SYSTEMS
ARRS basic reserach project: J1-2014
Principal Investigator: dr. Janez Mavri
Bilateral projects
II. DEVELOPMENT OF INHIBITORS OF HUMAN DNA TOPOISOMERASE IIα AND Mcl-1 PROTEIN AS NOVEL ANTICANCER AGENTS
ARRS US-SI bilateral reserach project: ARRS-BI/US-18-20-068
University of Michigan, USA (prof. Nikolovska Coleska)
Principal investigator: dr. Andrej Perdih
Joint publication: Discovery and characterization of 2,5-substituted benzoic acid dual inhibitors of the anti-apoptotic Mcl-1 and Bfl-1 proteins. (Link)
I. DEVELOPMENT OF NOVEL SELECTIVE SMALL MOLECULE INHIBITORS OF MCL-1 PROTEIN AND HUMAN DNA TOPOISOMERASE IIα
ARRS US-SI bilateral reserach project: ARRS-BI/US-16-17-036
University of Michigan, USA (prof. Nikolovska Coleska)
Principal investigator: dr. Andrej Perdih
Joint publication: Discovery of Mcl-1 inhibitors from integrated high throughput and virtual screening (Link)
