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Departments

Department of Synthetic Biology and Immunology

Research of the molecular mechanism of molecular recognition and signaling in innate immune response, drug design and synthetic biology.

 

Co-workers

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Representative Publications

  1. PRAZNIK, Arne, FINK, Tina, FRANKO, Nik, LONZARIĆ, Jan, BENČINA, Mojca, JERALA, Nina, PLAPER, Tjaša, ROŠKAR, Simona, JERALA, Roman. Regulation of protein secretion through chemical regulation of endoplasmic reticulum retention signal cleavage. Nature Communications. 2022, 13, Article number: 1323.
  2. AUPIČ, Jana, STRMŠEK, Žiga, LAPENTA, Fabio, Pahovnik, David, Pisanski, Tomaž, DROBNAK, Igor, LJUBETIČ, Ajasja, JERALA, Roman. Designed folding pathway of modular coiled-coil-based proteinsNature communications. 2021, 12, 1-12.
  3. LAPENTA Fabio, AUPIČ Jana, VEZZOLI Marco, STRMŠEK Žiga, Da Vela Stefano, Svergun Dmitri, Carazo Jose Maria, Melero, Roberto, JERALA Roman. Self-assembly and regulation of protein cages from pre-organised coiled-coil modules. Nature Communications. 2021, 12(1):939.
  4. Evavold, Charles L., HAFNER BRATKOVIČ, Iva, Devant, Pascal, Dʼandrea, Jasmin M., Ngwa, Elsy M., BORŠIĆ, Elvira, Doench, John G., Lafleur, Martin W., Sharpe, Arlene H., Thiagarajah, Jay R., Kagan, Jonathan C. Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway. Cell. 2021, 184, 4495-4511.
  5. HA, Van Thai, LAINŠČEK, Duško,Gesslbauer, Bernd, Jarc Jovičić, Eva, Hyötyläinen, Tuulia, Ilc, Nejc, Lakota, Katja, Tomšič, Matija, Van De Loo, Fons A. J., Bochkov, Valery, Petan, Toni, JERALA, Roman, MANČEK KEBER, Mateja. Synergy between 15-lipoxygenase and secreted PLA2 promotes inflammation by formation of TLR4 agonists from extracellular vesicles. PNAS 2020, 117, 25679-25689.
  6. LEBAR, Tina, LAINŠČEK, Duško, MERLJAK, Estera, AUPIČ, Jana, JERALA, Roman. A tunable orthogonal coiled-coil interaction toolbox for engineering mammalian cellsNature chemical biology, 2020, 16, 513–519.
  7. FINK, Tina, LONZARIĆ, Jan, PRAZNIK, Arne, PLAPER, Tjaša, MERLJAK, Estera, LEBEN, Katja, JERALA, Nina, LEBAR, Tina, STRMŠEK, Žiga, LAPENTA, Fabio, BENČINA, Mojca, JERALA, Roman. Design of fast proteolysis-based signaling and logic circuits in mammalian cells. Nature chemical biology, 2019, 15, 115-122.
  8. LEBAR, Tina, VERBIČ, Anže, LJUBETIČ, Ajasja, JERALA, Roman. Polarized displacement by transcription activator-like effectors for regulatory circuits. Nature chemical biology, 2019, 15, 80-87.
  9. HAFNER BRATKOVIČ, Iva, SUŠJAN, Petra, LAINŠČEK, Duško, Tapia-Abellán, Ana, CEROVIĆ, Kosta, KADUNC, Lucija, Angosto-Bazarra, Diego, Pelegrin, Pablo, JERALA, Roman. NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathwayNature communications, 2018, 9, 5182, 1-18.
  10. LJUBETIČ, Ajasja, LAPENTA, Fabio, GRADIŠAR, Helena, DROBNAK, Igor, AUPIČ, Jana, STRMŠEK, Žiga, LAINŠČEK, Duško, HAFNER-BRATKOVIČ, Iva,  MAJERLE, Andreja, KRIVEC, Nuša, BENČINA, Mojca, Pisanski, Tomaž Ćirković Veličković, Tanja, Round, Adam, Carazo, José María, Melero, Roberto, JERALA, Roman. Design of coiled-coil protein origami cages that self-assemble in vitro and in vivo. Nature Biotechnology, 2017, 1-8.
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