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Departments

Research activities

The two main research directions of the department are synthetic biology and molecular immunology.

Synthetic biology combines the engineering approach and biological systems, aiming to introduce new properties into biological or biomimetic systems including potential applications but also to understand the function of complex biological systems by the bottom up construction. Our main directions in synthetic biology include
i) designed bionanostructures (ERC Adg MaCChines),
ii) engineering of mammalian cell signaling and information processing and
iii) translational immunology.

Research in molecular immunity has been primarily dedicated to investigate the molecular mechanisms of innate immune signaling, particularly Toll-like receptors and inflammasome and recently also signaling via T-cell receptor for CAR therapy.

A strong emphasis of our laboratory is regarding the transfer enthusiasm for research to young generations. From 2006 till 2016 we supervised six student teams that competed at the international competition in synthetic biology iGEM. We are proud of their excellent achievements, that include also winning grand prize of the competition. Department was also coordinating a project for high-school students Next generation of life sciences researchers.

Research projects

No.Project titlePI
V4-2038DNA vaccines and peptide inhibitors against SARS-CoV-2prof. dr. Roman Jerala
Z4-2657Phosphorylation signaling pathway design in mammalian cellsdr. Tina Fink
N1-0125Chemically enhanced coiled-coil protein origami: towards designed molecular machinesdr. Tamara Šmidlehner
J4-1779Sonogenetics -ultrasound modulation of target gene expressiondr. Mojca Benčina
J3-1746The functional role of cell death in different NLRP3 inflammasomeactivation pathways and its application for innovative cancer immunotherapydr. Iva Hafner Bratkovič
J1-1711Designed protein origami based receptors: functionalized designed protein nanostructures for the recognition of the selected targetsdr. Helena Gradišar
J3-9257Molecular mechanism of endogenous TLR4 agonist formation and its role in chronic inflammatory diseases
J1-9173Design of a fast signaling and logic processing pathway based on orthogonal proteasesprof. dr. Roman Jerala
J3-9268Cancer immunotherapy modulation by ultrasounddr. Mojca Benčina
Z3-9260Intercellular transfer of the signaling complex by the extracellular vesicles secreted from the WM-associated MyD88 mutation carrying cellsdr. Vida Forstnerič
Z3-9276Advanced nano-vaccines based on protein origami combining activators of innate and adaptive immune responsedr. Duško Lainšček
N4-0080Optimizacija sinteznobioloških genskih vezij in reprogramiranja celic s pomočjo mikrofluidikeprof. dr. Roman Jerala
J3-8196Intercellular transfer of the signaling complex by the extracellular vesicles secreted from the WM-associated MyD88 mutation carrying cellsdr. Mateja Manček Keber
J3-7034Advanced nano-vaccines based on protein origami combining activators of innate and adaptive immune responsedr. Mojca Benčina
N4-0037In vivo folding of designed proteinprof. dr. Roman Jerala
J3-6784The molecular mechanism of single stranded DNA signaling via intracellular Toll-like receptor 9dr. Mojca Benčina
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