We are interested in inflammasomes, potent cytosolic proinflammatory machines that are on one hand important protectors against pathogens, but on the other hand, also promote inflammation in various non-communicable aging-related diseases. Inflammasome activation leads to the activation of inflammatory caspases that in turn activate proinflammatory cytokines IL-1b and IL-18 and gasdermin D to trigger pyroptosis. We are also building inflammasomes from scratch to either gain important mechanistic insight into a natural pathway or to help the immune system to fight threats that otherwise remain undetected, such as cancer.
Students, interested to join our endeavor, write to iva(dot)hafner(at)ki(dot)si .
Evavold1, CL, Hafner Bratkovič1, I, Devant, P, DʼAndrea, JM., Ngwa, EM, Boršić, E, Doench, JG, Lafleur, MW, Sharpe, AH, Thiagarajah, JR, Kagan, JC. Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway. Cell (2021), 184 (17): 4495-4511. DOI: 10.1016/j.cell.2021.06.028 1equal contribution
Devant1, P, Boršić1, E, Ngwa1, EM, Xiao, H., Chouchani, ET, Thiagarajah*,JR, Hafner-Bratkovič*,I, Evavold*, CL, Kagan*, JC. Gasdermin D pore-forming activity is redox sensitive. Cell Reports (2023), 42(1):112008. DOI: 10.1016/j.celrep.2023.112008 1equal contribution
Hafner Bratkovič*, I, Sušjan, P, Lainšček, D, Tapia-Abellán, A, Cerović, Ko, Kadunc, L, Angosto-Bazarra, D, Pelegrin, P, Jerala*, R. NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway. Nature communications (2018), 9: 5182 DOI: 10.1038/s41467-018-07573-4
Sušjan, P, Lainšček, D, Strmšek, Ž, Hodnik, V, Anderluh, G, Hafner Bratkovič, I*. Selective inhibition of NLRP3 inflammasome by designed peptide originating from ASC. The FASEB journal (2020), 34(8):11068-11086. CI 4/4 DOI: 10.1096/fj.201902938RR
Sušjan, P, Benčina, M, Hafner Bratkovič, I*. Differential effect of extracellular acidic environment on IL−1βIL−1β released from human and mouse phagocytes. International journal of molecular sciences (2020), 21 (19):7229-1-7229-16. CI 6/7 DOI: 10.3390/ijms21197229