Substituted bithiazoles for safer combinational chemotherapy treatments
Cancer is one of the most widespread diseases and the second leading cause of death, with WHO reporting almost 10 million deaths annually.
New antibacterial agents
The researchers have developed new antibacterial agents from the class of novel bacterial topoisomerase inhibitors (NBTIs) with innovative right hand side fragments that provide excellent overall antibacterial potency against a wide panel of Gram-positive and Gram-negative bacterial pathogens.
Design of split-superantigen for a safer cancer immunotherapy
Split-superantigen can stimulate up to 25% of body’s T cells to induce the immune response.
Small molecule inhibitors for cancer treatment
The pivotal feature of deregulated energetic metabolism of cancer cells is posttranslational modification of 6-phosphofructo-1-kinase (PFK1), the key regulatory enzyme of glycolysis.
Biological sensors and chemical biologicaal regulators
The invention relates to chemically inducible split protein actuators (CISPA), particularly to their design, manufacture, structure and uses.
A novel method for preparation of a hexameric biological nanopore
Nanopore technology is important in biotechnology for applications such as nanopore sensing and nanopore sequencing.
Cell-based device for local treatment with therapeutic proteins
A therapeutic device with therapeutic cells that secrete a combination of therapeutic proteins. The therapeutic cells are stored in a semi-permeable chamber that enables the exchange of nutritional substances and therapeutic proteins.
COVID-19 vaccine platform based on fusion of antigen domain to small hypoimmune scaffold
The Covid-19 pandemic is a major threat to the public health and economies. Effective vaccines based on new technologies represent the main hope to stop it.
LAMP Sars-CoV test
We have developed a sample buffer (consisting of a modified RNA stabilisation buffer, the RNA inhibitor Rnasecure, and a polymeric chelator, Chelex100) for the stabilisation of viral RNA and a sampling method that is fast and simple.
Coiled-coil mediated tethering of CRISPR/CAS and exonucleases for enhanced genome editing
The invention is CRISRP/Cas9 tethered with exonucleases, such as EXOIII or others. Tethering is achieved in a cell and uses heterodimeric peptide pairs, linked to Cas9 and exonuclease, which form a coiled-coil due to hydrophobic and electrostatic interactions.
Agricultural crop protection
The lack of efficient methods to control the major diseases of crops most important to agriculture leads to huge economic losses and seriously threatens global food security.