New findings about the mechanism of membrane transport identified as breaking journal article for Global Medical Discovery Series
The research team of the Laboratory of Chemometrics has publish recently the study on transmembrane domains of a membrane transporter bilitranslocase: "Structural Analysis of a Peptide Fragment of Transmembrane Transporter Protein Bilitranslocas", PLoS one, 2012; 7(6): e38967.
The challenge discussed in the article is to demonstrate that bilitranslocase is able to transport drugs through the cell membrane. The publication attracted the attention of the Target Selection team of Global Medical Discovery Series. They invited the authors to prepare a short summary and published it, along with the link to the original publication, in the Global Medical Discovery [ISSN 1929-8536]:
Global Medical Discovery service alerts the scientific community to breaking journal articles considered to be of importance to the drug discovery process. Global Medical Discovery is viewed almost 365,000 times each month by the audience of academic and industrial R&D personnel and it is featured on the intranets of a growing number of the top 40 BioPharmaceutical companies and major academic institutions. For this reason, the authors of the selected publication are especially motivated to continue with the research topic, which was initiated by the collaboration with Sabina Passamonti, Professor at the University of Trieste, and is extended through the inter-regional strategic research project TRANS2CARE.
The results obtained so far indicate that bilitranslocase might be an important membrane transporter for antioxidants as well as for nucleotides and nucleosides, and most probably also for certain drugs.
