Odseki

Raziskave molekularnega mehanizma prepoznavanja in signalizacije naravnega imunskega odziva, vnetnih bolezni in raka ter sintezna biologija.

1. PLAPER, Tjaša., MERLJAK, Estera., FINK, Tina, SATLER Tadej, LJUBETIČ, Ajasja, LAINŠČEK, Duško, JAZBEC, Vid, BENČINA, Mojca, STEVANOSKA, Sintija, DŽEROSKI, Sašo, JERALA, Roman. Designed allosteric protein logic. Cell Discovery 10, 8 (2024).
2. SATLER, Tadej, HADŽI, San, JERALA, Roman. Crystal structure of de novo designed coiled-coil protein origami triangle. Journal of the American Chemical Society. 2023, 145, 31, 16995–17000.
3. RIHTAR, Erik, LEBAR, Tina, LAINŠČEK, Duško, KORES, Katarina, LEŠNIK, Samo, BREN, Urban, JERALA, Roman. Chemically inducible split protein regulators for mammalian cells. Nature chemical biology. 2023, 19, 64-71.
4. RAMŠAK, Maruša, RAMIREZ, Dominique A., HOUGH, Loren E., SHIRTS, Michael R., VIDMAR, Sara, ELERŠIČ FILIPIČ, Kristina, ANDERLUH, Gregor, JERALA, Roman. Programmable de novo designed coiled coil-mediated phase separation in mammalian cells. Nature communications. 2023, 14, 7973, 1-15.
5. LAINŠČEK, Duško, GOLOB URBANC, Anja, MIKOLIČ, Veronika, PANTOVIĆ, Jelica, MALENŠEK, Špela, JERALA, Roman. Regulation of CD19 CAR-T cell activation based on an engineered downstream transcription factor. Molecular therapy oncolytics. Jun. 15, 2023, 29, 77-90.
6. MERLJAK, Estera, MALOVRH, Benjamin, JERALA, Roman. Segmentation strategy of de novo designed four-helical bundles expands protein oligomerization modalities for cell regulation. Nature communications. 2023, 14, 1995, 1-12.
7. LAINŠČEK, Duško, FORSTNERIČ, Vida, MIKOLIČ, Veronika, MALENŠEK, Špela, PEČAN, Peter, BENČINA, Mojca, SEVER, Matjaž, PODGORNIK, Helena, JERALA, Roman. Coiled-coil heterodimer-based recruitment of an exonuclease to CRISPR/Cas for enhanced gene editing. Nature communications. 23 Jun. 2022, 13, 1-12.
8. AUPIČ, Jana, LAPENTA, Fabio, STRMŠEK, Žiga, MERLJAK, Estera, PLAPER, Tjaša, JERALA, Roman. Metal ion-regulated assembly of designed modular protein cages. Science advances. 17 Jun. 2022, 8, 24, 1-12.
9. PRAZNIK, Arne, FINK, Tina, FRANKO, Nik, LONZARIĆ, Jan, BENČINA, Mojca, JERALA, Nina, PLAPER, Tjaša, ROŠKAR, Simona, JERALA, Roman. Regulation of protein secretion through chemical regulation of endoplasmic reticulum retention signal cleavage. Nature Communications. 2022, 13, Article number: 1323.
10. AUPIČ, Jana, STRMŠEK, Žiga, LAPENTA, Fabio, Pahovnik, David, Pisanski, Tomaž, DROBNAK, Igor, LJUBETIČ, Ajasja, JERALA, Roman. Designed folding pathway of modular coiled-coil-based proteins. Nature communications. 2021, 12, 1-12.
11. LAPENTA Fabio, AUPIČ Jana, VEZZOLI Marco, STRMŠEK Žiga, Da Vela Stefano, Svergun Dmitri, Carazo Jose Maria, Melero, Roberto, JERALA Roman. Self-assembly and regulation of protein cages from pre-organised coiled-coil modules. Nature Communications. 2021, 12(1):939.
12. Evavold, Charles L., HAFNER BRATKOVIČ, Iva, Devant, Pascal, Dʼandrea, Jasmin M., Ngwa, Elsy M., BORŠIĆ, Elvira, Doench, John G., Lafleur, Martin W., Sharpe, Arlene H., Thiagarajah, Jay R., Kagan, Jonathan C. Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway. Cell. 2021, 184, 4495-4511.