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    Centre for the Technologies of Gene and Cell Therapy

    Our goal is to build a pipeline of diversified biomedical tools focused on the development of therapeutic solutions for rare genetic diseases and difficult-to-treat cancers. We will develop novel gene therapies, cell therapies and immunotherapies.

    Webpage: https://ctgct.si/en/

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    Representative Publications

    1. Grošelj, U., Kavčič, M., Drole Torkar, A., Kafol, J., Lainšček, D., Jerala, R., Sever, M., Zver, S., Serša, G., Čemažar, M., Strojan, P., Grošelj, A., Žerjav Tanšek, M., Miroševič, Š., Ivančan, S., Prelog, T., Gosar, D., Oražem Mrak, J., Mlinarič, M.,  Bertok, S., Kovač, J., Kodrič, J., Battelino, S., Pokorn, M.,Ihan, A., Jazbec, J., Battelino, T., Osredkar, D. (2025). In Orphanet Journal of Rare Diseases (Vol. 20, Issue 1). BioMed Central Ltd. https://doi.org/10.1186/s13023-025-03828-8

    2. Maruna, M., Sušjan-Leite, P., Meško, M., Miroševič, Š., & Jerala, R. (2025). Molecular Therapy Nucleic Acids, 36(3). https://doi.org/10.1016/j.omtn.2025.102680

    3. Žakelj, N., Gosar, D., Miroševič, Š., Sanders, S. J., Ljungdahl, A., Kohani, S., Huang, S., Leong, L. I., An, Y., Teo, M. J., Moultrie, F., Jerala, R., Lainšček, D., Forstnerič, V., Sušjan, P., Lisowski, L., Perez-Iturralde, A., Mrak, J. O., Chan, H. Y. E., & Osredkar, D. (2025). Human Genetics and Genomics Advances, 6(4). https://doi.org/10.1016/j.xhgg.2025.100483

    4. Boršić, E., Ramuta, T. Ž., Orehek, S., Kreft, M. E., Geyer, M., Jerala, R., & Hafner-Bratkovič, I. (2025). Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly. Nature Communications, 16(1), 4887. doi.org/10.1038/s41467-025-60277-4

    5. Plaper, T., Štibler, U. K., & Jerala, R. (2025). Synthetic Biology for Designing Allostery and its Potential Biomedical Applications. Journal of Molecular Biology, 169225. doi.org/10.1016/j.jmb.2025.169225

    6. Ivanovski, F., Jazbec, V., Varda, N., Jerala, R., & Benčina, M. (2025). Ultrasound-responsive mammalian cell synthetic biology. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 1–1. doi.org/10.1109/TUFFC.2025.3570813

    7. Miroševič, Š., Khandelwal, S., Amerson, E., Parks, E., Parks, M., Cochran, L., González Hernández, A., Ferraro, M., Lisowski, L., Perez-Iturralde, A., Chung, W., Jacob, M. H., Žakelj, N., Lainšček, D., Forstnerič, V., Sušjan, P., Maruna, M., Jerala, R., & Osredkar, D. (2025). Paving the way toward treatment solutions for CTNNB1 syndrome: a patient organization perspective. Therapeutic Advances in Rare Disease, 6. doi.org/10.1177/26330040251318355

    8. Rihtar, E., Fink, T., Lebar, T., Lainšček, D., Kolenc, Ž., Polajnar, L. K., & Jerala, R. (2025). Ligand-induced assembly of antibody variable fragments for the chemical regulation of biological processes. Cell Chemical Biology. doi.org/10.1016/j.chembiol.2025.01.007

    9. Orehek, S., Ramuta, T. Ž., Lainšček, D., Malenšek, Š., Šala, M., Benčina, M., Jerala, R., & Hafner-Bratkovič, I. (2024). Cytokine-armed pyroptosis induces antitumor immunity against diverse types of tumors. Nature Communications , 15(1). doi.org/10.1038/s41467-024-55083-3

    10. Presen, D. M., Lainšček, D., Kinghorn, J., Sebestyen, Z., Kuball, J., Amini, L., Reinke, P., Fuchs, A., Jerala, R., & Benčina, M. (2024). CTGCT, Centre of Excellence for the Technologies of Gene and Cell Therapy: Collaborative Translation of Scientific Discoveries into Advanced Treatments for Neurological Rare Genetic Diseases and Cancer. Computational and Structural Biotechnology Journal. doi.org/10.1016/j.csbj.2024.11.051

    11. Lainšček, D., Horvat, S., Dolinar, K., Ivanovski, F., Romih, R., Pirkmajer, S., Jerala, R., & Manček-Keber, M. (2024). MyD88 protein destabilization mitigates NF-κB-dependent protection against macrophage apoptosis. Cell Communication and Signaling, 22(1), 549. https://doi.org/10.1186/s12964-024-01930-1

    12. Ivanovski, F., Meško, M., Lebar, T., Rupnik, M., Lainšček, D., Gradišek, M., Jerala, R., & Benčina, M. (2024). Ultrasound-mediated spatial and temporal control of engineered cells in vivo. Nature Communications, 15(1), 7369. doi.org/10.1038/s41467-024-51620-2

    13. Mezgec, K., Snoj, J., Ulčakar, L., Ljubetič, A., Tušek Žnidarič, M., Škarabot, M., & Jerala, R. (2024). Coupling of Spectrin Repeat Modules for the Assembly of Nanorods and Presentation of Protein Domains. ACS Nano. doi.org/10.1021/acsnano.4c07701
    14. Plaper, T., Rihtar, E., Železnik Ramuta, T., Forstnerič, V., Jazbec, V., Ivanovski, F., Benčina, M., & Jerala, R. (2024). The art of designed coiled-coils for the regulation of mammalian cells. In Cell Chemical Biology. Elsevier Ltd. doi.org/10.1016/j.chembiol.2024.06.001
    15. Jazbec, V., Varda, N., Šprager, E., Meško, M., Vidmar, S., Romih, R., Podobnik, M., Kežar, A., Jerala, R., & Benčina, M. (2024). Protein Gas Vesicles of Bacillus megaterium as Enhancers of Ultrasound-Induced Transcriptional Regulation. ACS Nano, 18(26), 16692–16700. doi.org/10.1021/acsnano.4c01498
    16. Esih, H., Mezgec, K., Billmeier, M., Malenšek, Š., Benčina, M., Grilc, B., Vidmar, S., Gašperlin, M., Bele, M., Zidarn, M., Zupanc, T. L., Morgan, T., Jordan, I., Sandig, V., Schrödel, S., Thirion, C., Protzer, U., Wagner, R., Lainšček, D., & Jerala, R. (2024). Mucoadhesive film for oral delivery of vaccines for protection of the respiratory tract. Journal of Controlled Release, 371, 179–192. doi.org/10.1016/j.jconrel.2024.05.041
    17. Plaper, T., Merljak, E., Fink, T., Satler, T., Ljubetič, A., Lainšček, D., Jazbec, V., Benčina, M., Stevanoska, S., Džeroski, S., & Jerala, R. (2024). Designed allosteric protein logic. Cell Discovery, 10(1). doi.org/10.1038/s41421-023-00635-y
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