Center za tehnologije genske in celične terapije
Naš cilj je razvoj niza raznolikih biomedicinskih orodij, usmerjenih v pripravo terapevtskih rešitev za redke genetske bolezni in težko ozdravljive rake. Razvijali bomo nove genske terapije, celične terapije in imunoterapije.
Webpage: https://ctgct.si/en/
Sodelavke in sodelavci
Vodja odseka
Predstavitvene publikacije
Boršić, E., Ramuta, T. Ž., Orehek, S., Kreft, M. E., Geyer, M., Jerala, R., & Hafner-Bratkovič, I. (2025). Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly. Nature Communications, 16(1), 4887. doi.org/10.1038/s41467-025-60277-4
Plaper, T., Štibler, U. K., & Jerala, R. (2025). Synthetic Biology for Designing Allostery and its Potential Biomedical Applications. Journal of Molecular Biology, 169225. doi.org/10.1016/j.jmb.2025.169225
Ivanovski, F., Jazbec, V., Varda, N., Jerala, R., & Benčina, M. (2025). Ultrasound-responsive mammalian cell synthetic biology. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 1–1. doi.org/10.1109/TUFFC.2025.3570813
Miroševič, Š., Khandelwal, S., Amerson, E., Parks, E., Parks, M., Cochran, L., González Hernández, A., Ferraro, M., Lisowski, L., Perez-Iturralde, A., Chung, W., Jacob, M. H., Žakelj, N., Lainšček, D., Forstnerič, V., Sušjan, P., Maruna, M., Jerala, R., & Osredkar, D. (2025). Paving the way toward treatment solutions for CTNNB1 syndrome: a patient organization perspective. Therapeutic Advances in Rare Disease, 6. doi.org/10.1177/26330040251318355
Rihtar, E., Fink, T., Lebar, T., Lainšček, D., Kolenc, Ž., Polajnar, L. K., & Jerala, R. (2025). Ligand-induced assembly of antibody variable fragments for the chemical regulation of biological processes. Cell Chemical Biology. doi.org/10.1016/j.chembiol.2025.01.007
Orehek, S., Ramuta, T. Ž., Lainšček, D., Malenšek, Š., Šala, M., Benčina, M., Jerala, R., & Hafner-Bratkovič, I. (2024). Cytokine-armed pyroptosis induces antitumor immunity against diverse types of tumors. Nature Communications , 15(1). doi.org/10.1038/s41467-024-55083-3
Presen, D. M., Lainšček, D., Kinghorn, J., Sebestyen, Z., Kuball, J., Amini, L., Reinke, P., Fuchs, A., Jerala, R., & Benčina, M. (2024). CTGCT, Centre of Excellence for the Technologies of Gene and Cell Therapy: Collaborative Translation of Scientific Discoveries into Advanced Treatments for Neurological Rare Genetic Diseases and Cancer. Computational and Structural Biotechnology Journal. doi.org/10.1016/j.csbj.2024.11.051
Lainšček, D., Horvat, S., Dolinar, K., Ivanovski, F., Romih, R., Pirkmajer, S., Jerala, R., & Manček-Keber, M. (2024). MyD88 protein destabilization mitigates NF-κB-dependent protection against macrophage apoptosis. Cell Communication and Signaling, 22(1), 549. doi.org/10.1186/s12964-024-01930-1
- Ivanovski, F., Meško, M., Lebar, T., Rupnik, M., Lainšček, D., Gradišek, M., Jerala, R., & Benčina, M. (2024). Ultrasound-mediated spatial and temporal control of engineered cells in vivo. Nature Communications, 15(1), 7369. doi.org/10.1038/s41467-024-51620-2
- Mezgec, K., Snoj, J., Ulčakar, L., Ljubetič, A., Tušek Žnidarič, M., Škarabot, M., & Jerala, R. (2024). Coupling of Spectrin Repeat Modules for the Assembly of Nanorods and Presentation of Protein Domains. ACS Nano. doi.org/10.1021/acsnano.4c07701
- Plaper, T., Rihtar, E., Železnik Ramuta, T., Forstnerič, V., Jazbec, V., Ivanovski, F., Benčina, M., & Jerala, R. (2024). The art of designed coiled-coils for the regulation of mammalian cells. In Cell Chemical Biology. Elsevier Ltd. doi.org/10.1016/j.chembiol.2024.06.001
- Jazbec, V., Varda, N., Šprager, E., Meško, M., Vidmar, S., Romih, R., Podobnik, M., Kežar, A., Jerala, R., & Benčina, M. (2024). Protein Gas Vesicles of Bacillus megaterium as Enhancers of Ultrasound-Induced Transcriptional Regulation. ACS Nano, 18(26), 16692–16700. doi.org/10.1021/acsnano.4c01498
- Esih, H., Mezgec, K., Billmeier, M., Malenšek, Š., Benčina, M., Grilc, B., Vidmar, S., Gašperlin, M., Bele, M., Zidarn, M., Zupanc, T. L., Morgan, T., Jordan, I., Sandig, V., Schrödel, S., Thirion, C., Protzer, U., Wagner, R., Lainšček, D., & Jerala, R. (2024). Mucoadhesive film for oral delivery of vaccines for protection of the respiratory tract. Journal of Controlled Release, 371, 179–192. doi.org/10.1016/j.jconrel.2024.05.041
- Plaper, T., Merljak, E., Fink, T., Satler, T., Ljubetič, A., Lainšček, D., Jazbec, V., Benčina, M., Stevanoska, S., Džeroski, S., & Jerala, R. (2024). Designed allosteric protein logic. Cell Discovery, 10(1). doi.org/10.1038/s41421-023-00635-y