Odseki

Proučujemo interakcije med biološkimi molekulami na molekulski ravni z uporabo pristopov biokemije, biofizike in strukturne biologije, da bi razložili njihov mehanizem delovanja, kot tudi možnosti uporabe v (nano)biotehnologiji.

1. Koritnik N, Kežar A, Kavčič L, Žnidarič MT, Leonardi A, De S, Pollari M, Mäkinen K, Podobnik M. Species-specific structural adaptation of the potyviral coat protein in virions and virus-like particles. Communications Biology 2026; 9(1):226. DOI: 10.1038/s42003-025-09502-w

2. Gameiro PA, Foskolou IP, Butt YA, Martens AAM, Kuret Hodnik K, Ruiz de Los Mozos I, Zandhuis ND, Hozjan Ž, Kot VM, Faraway R, Vermeulen M, Wolkers MC, Johnson RS, Ule J. Meta-unstable mRNAs in activated CD8+ T cells are defined by interlinked AU-rich elements and m6A mRNA methylation. Nature Communications 2026;17(1):160. DOI: 10.1038/s41467-025-67762-w

3. Srnko M, Šolinc G, Crnković A, Merzel F, Jordan M, Wallace EJ, Podobnik M, Anderluh G. High-Throughput Human Histone Detection by an Engineered Actinoporin Nanopore. ACS Sensors 2026;11(3):2016-2029. DOI: 10.1021/acssensors.5c03533

4. Kalanj NŽ, Prešern A, Naumoska K, Snoj T, Aupič J, Glavnik V, Albreht A, Mally M, Derganc J, Greimel P, Magistrato A, Anderluh G. Plasticity of the cytotoxic Nep1-like protein enables promiscuity in binding to its lipid receptor glycosylinositol phosphorylceramides. Science Advances 2025; 11(41):eadw6401. DOI: 10.1126/sciadv.adw6401

5. Šolinc G, Srnko M, Merzel F, Crnković A, Kozorog M, Podobnik M*, Anderluh G.* Cryo-EM structures of a protein pore reveal a cluster of cholesterol molecules and diverse roles of membrane lipids. Nature Communications 2025; 16(1):2972. DOI: 10.1038/s41467-025-58334-z

6. Faraway R, Costello Heaven N, Digby H, Kuret Hodnik K, Rebselj J, Wilkins OG, Chakrabarti AM, Iosub IA, Vadnjal N, Dore R, Knez L, Ameres SL, Plaschka C, Ule J. Collective homeostasis of condensation-prone proteins via their mRNAs. Nature 2025; 647(8090):798-808; DOI: 10.1038/s41586-025-09568-w

7. Kavčič L, Kežar A, Koritnik N, Žnidarič MT, Klobučar T, Vičič Ž, Merzel F, Holden E, Benesch JLP, Podobnik M. From structural polymorphism to structural metamorphosis of the coat protein of flexuous filamentous potato virus Y. Communication Chemistry 2024; 7(1):14. DOI: 10.1038/s42004-024-01100-x

8. Petrišič N, Adamek M, Kežar A, Hočevar SB, Žagar E, Anderluh G, Podobnik M. Structural basis for the unique molecular properties of broad-range phospholipase C from Listeria monocytogenes. Nature Communications 2023; 14(1):6474. DOI: 10.1038/s41467-023-42134-4

9. Pirc K, Clifton LA, Yilmaz N, Saltalamacchia A, Mally M, Snoj T, Žnidaršič N, Srnko M, Borišek J, Parkkila P, Albert I, Podobnik M, Numata K, Nürnberger T, Viitala T, Derganc J, Magistrato A, Lakey JH, Anderluh G. An oomycete NLP cytolysin forms transient small pores in lipid membranes. Science Advances 2022, 8(10):eabj9406. DOI: 10.1126/sciadv.abj9406

10. Kuret K, Amalietti AG, Jones DM, Capitanchik C, Ule J. Positional motif analysis reveals the extent of specificity of protein-RNA interactions observed by CLIP. Genome Biology 2022; 23(1):191. DOI: 10.1186/s13059-022-02755-2