Departments

2004-2009     PhD in Medicinal Chemistry

Dynamical Model of the E. coli MurD enzyme and in silico design of novel inhibitors

                      University of Ljubljana, Slovenia

1999-2004     Undergraduate Studies of Pharmacy

                       University of Ljubljana, Slovenia

2017 -             Senior Research Associate

                        National Institute of Chemistry, SI

2013-2017      Visiting Scholar  (15 months)

                        University of Michigan, USA

2012-2017      Research Associate

                        National Institute of Chemistry

2012 - 2013   Visiting Scholar  (14 months)

                       Freie Universität Berlin, Germany

2009-2012     Postdoctoral Researcher

                       National Institute of Chemistry, SI

2008              Visiting Scholar (4 months)

                      Inte:Ligand, Vienna, Austria

2004 - 2009    Junior Researcher (PhD student)

2021-           Associate Professor (Med. Chemistry)

                     University of Ljubljana

2011-2021  Assistant Professor (Med. Chemistry)

                    University of Ljubljana

2006-2011  Teaching assistant (Med. Chemistry)

                    Faculty of Pharmacy

2019                Publons award:Top peer reviewer  

2009                Krka prize for PhD. Thesis

2004                Krka prize for M. Pharm. Thesis

2004                Faculty of Pharmacy Award

1.  VIRTUAL SCREENING AND MOLECULAR DESIGN

Anticancer targets

1. BERGANT Kaja, JANEŽIČ Matej, ŠTAMPAR Martina, ŽEGURA Bojana, GOBEC Stanislav, FILIPIČ Metka, PERDIH Andrej. Substituted 4,5'-Bithiazoles as Catalytic Inhibitors of Human DNA Topoisomerase IIα, J. Chem. Inf. Model., 2020, 60, 3662–3678. Full text

2. HERLAH, Barbara, JANEŽIČ, Matej, OGRIS, Iza, GOLIČ GRDADOLNIK, Simona, KOLOŠA, Katja, ŽABKAR, Sonja, ŽEGURA, Bojana, PERDIH, Andrej. Nature-inspired substituted 3-(imidazol-2-yl) morpholines targeting human topoisomerase IIα : dynophore-derived discovery. Biomedicine & pharmacotherapy. 2024, 175, [article no.] 116676. Full text

Antibacterial targets

1. PERDIH, Andrej, HRAST, Martina, BARRETEAU, Hélène, GOBEC, Stanislav, WOLBER, Gerhard, ŠOLMAJER, Tomaž. Inhibitor design strategy based on an enzyme structural flexibility : a case of bacterial MurD ligase. J. Chem. Inf. Model., 2014, 54, 1451-1466. Full text

2. BRVAR, Matjaž, PERDIH, Andrej, RENKO, Miha, ANDERLUH, Gregor, TURK Dušan, ŠOLMAJER, Tomaž. Structure-based discovery of substituted 4,5’-bithiazoles as novel DNA gyrase inhibitors.  J. Med. Chem.  2012, 55, 6413−6426. Full text

2. MOLECULAR SIMULATIONS OF BIOMOLECULES

1. HERLAH, Barbara, PAVLIN, Matic, PERDIH, Andrej. Molecular choreography : unveiling the dynamic landscape of type IIA DNA topoisomerases before T-segment passage through all-atom simulations.International journal of biological macromolecules. 2024, vol. 269, [article no.] 131991. Full text

2. PAVLIN, Matic, HERLAH, Barbara, VALJAVEC, Katja, PERDIH, Andrej. Unveiling the interdomain dynamics of type II DNA topoisomerase through all-atom simulations : implications for understanding its catalytic cycle. Computational and Structural Biotechnology Journal. 2023, vol. 21, str. 3746-3759. Full text

3.  MODELING OF REACTION MECHANISMS

Enzymatic reactions

1. OGRIZEK, Mitja, JANEŽIČ, Matej, VALJAVEC, Katja, PERDIH, Andrej. Catalytic mechanism of ATP hydrolysis in the ATPase domain of human DNA topoisomerase IIα  J. Chem. Inf. Model., 2022, 62, 3896–3909. Full text

2. BORIŠEK, Jure, PINTAR, Sara, OGRIZEK, Mitja, TURK, Dušan, PERDIH, Andrej, NOVIČ, Marjana. A water-assisted catalytic mechanism in glycoside hydrolases demonstrated on the Staphylococcus aureus autolysin E. ACS catalysis, 2018, 8, 4334-4345. Full text

Organic reactions

1. RIČKO, Sebastijan, SVETE, Jurij, ŠTEFANE, Bogdan, PERDIH, Andrej, GOLOBIČ, Amalija, MEDEN, Anže, GROŠELJ, Uroš. 1,3-diamine-derived bifunctional organocatalyst prepared from camphor.Adv. Synth. Catal,2016, 358, 3786-3796. Full text

2. ŠTEFANE, Bogdan, PERDIH, Andrej, PEVEC, Andrej, ŠOLMAJER, Tomaž, KOČEVAR, Marijan. The participation of 2H-pyran-2-ones in [4+2] cycloadditions : an experimental and computational study. Eur. J. Org. Chem.2010, 30, 5870-5883. Full text

4. SELECTED REVIEW ARTICLES

1. PRAŠNIKAR Eva, BORIŠEK, Jure, PERDIH Andrej. Senescent cells as promising targets to tackle age-related diseases, Aging Research Reviews 2021, vol. 66, 101251. Full text

2. POGORELČNIK, Barbara, PERDIH, Andrej, ŠOLMAJER, Tomaž. Recent advances in the development of catalytic inhibitors of human DNA topoisomerase II[alpha] as novel anticancer agents. Curr. Med. Chem., 2013, 20, 694-709. Full text

2011 - Reviewer for most of the established journals in the fields of Medicinal and Computational Chemistry

WIREs Computational Molecular Science, Journal of Medicinal Chemistry, Scientific Reports, ACS Medicinal Chemistry Letters, Drug Discovery Today, ChemMedChem, Bioorg. & Med. Chem., Journal of Chemical Information and Modeling, Chemical Biology & Drug Design,Current Medicinal Chemistry, European Journal of Medicinal Chemistry, RSC Advances, etc.

2012 - Expert evaluator of grant proposals of several European reserach agencies