Studies of protein-RNA interactions and their cellular networks (Laboratory for RNA networks)
Ule’s group studies the assembly and function of protein-RNA complexes. The group is developing techniques such as iCLIP (individual-nucleotide resolution CLIP) and hybrid iCLIP (hiCLIP), along with new computational tools, to identify protein-RNA and RNA-RNA contacts in cells. These are used to unravel how protein-RNA complexes are assembled by combinatorial binding of proteins to RNA sequence and structures, and how intrinsically disordered regions (IDRs) of proteins contribute by additional contacts that promote condensation of such complexes. Moreover, we study the assembly principles that coordinate the regulation of RNA transcripts. This can lead to new understanding of the RNA mechanisms that go awry in diseases such as ALS, and opens new opportunities for their therapeutic modulation. For more information, visit www.ulelab.info.
