Departments

Our research focusses on the investigation of structure, dynamics and kinetics in biomolecular systems to reveal functional roles and molecular mechanisms. To achieve this, we combine linear and ultrafast fs vibrational spectroscopy, NMR spectroscopy and high-performance computing, accompanied by the most advanced theoretical and computational approaches to thoroughly analyze experimental and simulated data. Understanding molecular dynamics over different time scales is at the center of our scientific approach.

Our work influences and contributes to the rational design and development of drugs and to understanding the molecular basis of diseases.

I) Hydration, hydrophobicity, hydrogen bonds, aggregation

We investigate the physicochemical principles underlying solvation, protein structure, and aggregation. Our methods include vibrational spectroscopy combined with chemometric tools, and atomistic simulations.

II) Dynamics of biomolecular interactions

We aim to understand the kinetics and mechanisms of complex biomolecular processes. We use NMR spectroscopy combined with analytical tools, molecular dynamics, stochastic simulation methods, and self-developed computational approaches.

III) Disordered proteins, biocondensation, disease-related biomolecular modifications

We study the biological functions and dysfunctions of intrinsically disordered proteins, their role in cellular phase separation, and the range of biochemical modifications in tissues caused by diseases. We use vibrational and NMR spectroscopy, and simulation tools enhanced by theoretical and computational methods.