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Departments

Department of Synthetic Biology and Immunology

The two main research directions of the department are synthetic biology and molecular immunology. Synthetic biology combines the engineering approach and biological systems, aiming to introduce new properties into biological or biomimetic systems including potential applications but also to understand the function of complex biological systems by the bottom up construction.

Research in molecular immunity has been primarily dedicated to investigate the molecular mechanisms of innate immune signaling, particularly Toll-like receptors and inflammasome and recently also signaling via T-cell receptor for CAR therapy. More about department’s research interests read here.

Motivated postgraduate and postdoctoral students interested in developing new synthetic biology tools, studying the mechanisms of innate immunity signaling, or designing modular protein nanostructures are invited to address their interest and presentation to Prof. Roman Jerala (roman(dot)jerala(at)ki(dot)si).

Achievements

Dimeric coiled helices are structural motifs that often occur in natural proteins. They consist of α-helices that wind…

Proteins are key building blocks of all organisms. In recent years, we realized that new protein structures can be…

Structure prediction and design of smaller protein domains have advanced remarkably. On the other hand, understanding of…

Oxidative stress, which accompanies the sterile inflammation, induces release of extracellular vesicles (stressEVs),…

We report on the effective use of designed molecular pairs to regulate cell function, which will be useful for both…

News

Website of the CCEdit project, which is implemented within the ERC Proof-of-Concept, granted to prof. dr. Roman Jerala…

As part of NICKI 2021 Innovation Funding, a team of researchers from the Department of Synthetic Biology and Immunology…

Instead of targeting virus-specific proteins or enzymes by small molecules as done by current antivirals, researchers of…

L'Oréal Adria and the Slovenian National Commission for UNESCO awarded three promising young researchers this year with…

Prof. dr. Roman Jeralareceived the ERC Proof of Concept grant with project »CCEdit – Coiled-coil mediated exonuclease…

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