Synthesis of ellagic acid from ethyl gallate using hydroxides and deep eutectic solvents
Society is becoming increasingly conscious of how important a healthy lifestyle is and the role that natural plant products play in it. One such important natural compound is ellagic acid (EA) – a polyphenolic compound found in various fruits, vegetables, and other plant sources. EA has antioxidant, anti-mutagenic, anti-carcinogenic, anti-inflammatory, and antimicrobial properties.
Our invention describes a novel process for the efficient synthesis of this bioactive polyphenolic compound from gallic acid esters, such as methyl gallate, ethyl gallate, and propyl gallate. Our production method uses a combination of an alkaline solution, eutectic solvents, and a gas mixture.
The main benefits of the method we have developed include a high yield and purity – even on larger scales, where a 61.8% yield is still maintained. Furthermore, the reaction protocols are simple, ensuring both the accessibility and reproducibility of the newly developed approach.
Developed by: Department of Catalysis and Chemical Reaction Engineering.
Technology readiness level: TRL3.
Status of intellectual property: Patent granted.
Cooperation opportunities: Joint development, intellectual property licensing, or sale.
Scientific and academic papers
Cajnko, M. M., Prašnikar, A., Likozar, B. (2024). Hydroxide-Catalyzed Ellagic Acid Synthesis from Biobased Ethyl Gallate Using Deep Eutectic Solvents. ACS Sustainable Chem. Eng. 2024, 12, 10, 4007–4016. https://pubs.acs.org/doi/10.1021/acssuschemeng.3c06824.