We aim to design a virtual research environment to assist medical applications of ultrasound-guided drug and gene delivery and imaging. The project focus are the encapsulated microbubbles and gas vesicles with submicron size that are used as ultrasound contrast agents and can also act as drug carriers. We will develop new, data-informed mesoscopic models of ultrasound contrast agents to accurately model their rheological and acoustic behavior that critically affects the technology of ultrasound-guided drug and gene delivery. Interactions of ultrasound and agents at a submicron level will be included by harnessing high-performance computing (hpc) and employing novel multiscale methods that enable seamless propagation of ultrasound from the macro to microscopic level. The proposed framework will be integrated with experimental efforts to advance ultrasound-guided drug and gene delivery across biomedical applications.
https://cordis.europa.eu/project/id/885155
Sub-THz acoustic excitation of protein motion
P. Papež, F. Merzel, and M. Praprotnik, J. Chem. Phys. 159, 135101 (2023)